The GABA-A Receptor

Molecular Illustration, Biological Illustration, 3D Modelling

Description

This spread describes the function of the GABA-A receptor in the context of human health. Molecular imaging data was used to create 3-D models of small molecules and proteins.

Year

2022

Tools

Visual Molecular Imaging, UCSF Chimera, Autodesk Maya, Adobe Photoshop, Adobe Illustrator

Media

Print- two page magazine spread

Client

Derek Ng

Audience

Science interested lay audience

Process

Coming soon…

References

  • PDB ID: 6X3Z, 6D6T, 6D6U, 6X3X, 6X3W

  • PubChem ID: 4763, 119, 702, 3016, 3373, 92786, 5520

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  • Lorenz-Guertin, J. M., & Jacob, T. C. (2018). GABA type A receptor trafficking and the architecture of synaptic inhibition. Dev Neurobiol. 78(3), 238-270. Doi: 10.1002/dneu.22536

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  • Olson, R. W., & DeLorey, T. M. (1999). Siegel G. J. & Agranoff, B. W, eds. Basic neurochemistry: Molecular, cellular and medical aspects (6th ed.). Philadephia: Lippincott-Raven. https://www.ncbi.nlm.nih.gov/books/NBK28090/#:~:text=GABAB%20receptors%20are%20co upled,both%20postsynaptic%20and%20presynaptic%20inhibition.

  • Roy-Byrne, P. P. (2005) The GABA-Benzodiazepine receptor complex: structure, function, and role in anxiety. J Clin Psychiatry, 66(suppl 2), 14-20). https://www.psychiatrist.com/read-pdf/7555/

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  • Uusi-Oukari, M., & Korpi, E. R, (2010). Regulation of GABAA receptor subunit expression by pharmacological agents. Pharmacological Reviews, 62(1), 97-135

  • Zhu, S., Noviello, C. M., Teng, J., Walsh, R. M. Jr., Kim, J. J., & Hibbs, R. E. (2018). Structure of a human synaptic GABAA receptor. Nature, 559, 67-72. https://doi.org.10.1038/s41586-018-0255-3